Biomarkers for today's most promising drugs,
and tomorrow's life savers.
Enable Cdx development to increase the chance of clinical and commercial success. We construct clinically actionable signatures ready for lab validation.
- Identify molecular surrogates from accessible tissue for hard to measure phenotypes
- Develop predictive models robust to data platform and across patient populations
- Take advantage of flexible regulatory frameworks to optimize for trial success
Design and implement a precision medicine strategy. We stratify patient cohorts by molecular subtype or response profile to guide enriched trial design.
- Develop novel machine learning models based on integrative analysis of RNA and other patient data
- Evaluate and extend published models to your drug-specific datasets
- Leverage large public compendia (e.g. TCGA, CCLE) to inform your clinical strategy
Translate the biology of drug response. We interrogate first-in-human and experimental data to help decipher and predict effects in real patients.
- Examine gene pathways and networks that respond to treatment
- Evaluate and reformulate hypotheses regarding mechanism of action
- Plan the next set of clinical measurements based on rigorous data analysis