Precision Drug Discovery
Advance your drug program from the lab through the clinic with Genialis. Global experts in gene expression and genome regulation, Genialis helps companies of all sizes discover high confidence drug targets and biomarkers to find new ways to treat diseases of high unmet need.Contact us
Identify predictive gene signatures and develop patient classifiers.
We are experts in integrative analyses with RNA and other biological and patient data.
- Stratify patient cohorts by molecular subtype or response profile
- Evaluate and extend published models to apply to your trials
- Leverage large public compendia (e.g. TCGA, CCLE) to inform your clinical strategy
- Develop models robust to data platform and across patient populations
Find, prioritize & validate essential and specific gene products. We marry multi-omic integration with functional genomics to exploit disease vulnerability.
- Identify key drivers of disease from numerous lines of evidence
- Triage target candidates, keeping only those most likely to be effective
- Generate testable hypotheses for rapid in vitro and in vivo validation
- Tackle diseases and mechanisms previously dismissed as “undruggable”
Translate the biology of drug response. We investigate first-in-human and experimental data to help decipher and predict effects in real patients.
- Examine gene pathways and networks that respond to treatment
- Evaluate and reformulate hypotheses regarding mechanism of action
- Plan the next set of experiments or clinical measurements based on rigorous data analysis
- Synthesize results from disparate preclinical models and assays